Jamie Smith will open the batting for England in the first one-day international against West Indies as Harry Brook begins his tenure as permanent captain.
Smith, who averaged eight with a highest score of 15 while batting at No 3 in England's dismal Champions Trophy campaign in Pakistan earlier this year, will partner Ben Duckett at the top of the order at Edgbaston on Thursday, live on Sky Sports (1pm first ball).
New skipper Brook is slated to come in at No 4, behind Joe Root and ahead of the man he replaced as captain in Jos Buttler, who will also keep wicket in Birmingham.
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England XI to face West Indies in first ODI
Ben Duckett, Jamie Smith, Joe Root, Harry Brook (captain), Jos Buttler (wicketkeeper), Jacob Bethell, Will Jacks, Jamie Overton, Brydon Carse, Saqib Mahmood, Adil Rashid
Jacob Bethell and Will Jacks complete the top seven and will also assist Adil Rashid in the spin-bowling department, while Brydon Carse, now over a toe issue, will join Saqib Mahmood and Jamie Overton in the pace attack.
Fast bowlers Jofra Archer (thumb) and Gus Atkinson (hamstring) had already been ruled out of the ODI series through injuries.
Lancashire seamer Luke Wood was called up to replace Archer but is one of the four players in the 15-man group to sit out the series opener, alongside fellow bowler Matthew Potts, batter Tom Banton and left-arm spinner Tom Hartley.
England play further ODIs in Cardiff on Sunday (11am) and then The Kia Oval on June 3 (1pm) before the T20s take place in Durham (6.30pm on June 6), Bristol (2.30pm on June 8) and Southampton (6.30pm on June 10), all live on Sky Sports.
England vs West Indies fixtures
All times UK and Ireland, all live on Sky Sports
One-day international series
- First ODI: Thursday May 29 (1pm) - Edgbaston, Birmingham
- Second ODI: Sunday June 1 (11am) - Sophia Gardens, Cardiff
- Third ODI: Tuesday June 3 (1pm) - The Kia Oval, London
T20 international series
- First T20: Friday June 6 (6.30pm) - Seat Unique Riverside, Chester-le-Street
- Second T20: Sunday June 8 (2.30pm) - Seat Unique Stadium, Bristol
- Third T20: Tuesday June 10 (6.30pm) - Utilita Bowl, Southampton