Ben Stokes has been ruled out of England's fifth Test against India, with the hosts making four changes for the Kia Oval fixture.
It is understood Stokes has sustained a grade three muscle tear around his right shoulder, meaning a significant lay-off awaits the all-rounder.
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Also missing out are spinner Liam Dawson and pace bowlers Jofra Archer and Brydon Carse.
Stokes has been battling a variety of fitness issues over the course of the series and has finally been laid low with a problem that reared its head during last week's draw at Old Trafford.
England do not play Test cricket again until the Ashes this winter, meaning the 34-year-old could face a tight recovery period to be fit for the hotly-anticipated series.
England have included Jacob Bethell, who will bat at six. Gus Atkinson and Jamie Overton come into the side, along with Josh Tongue to make up a new pace attack.
With skipper Stokes out, Ollie Pope will take on the captaincy. Joe Root and Bethell are the spin options in the line-up.
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Meanwhile, India pace spearhead Jasprit Bumrah is not expected to play in the final Test.
Bumrah has already played three Tests in the series, the maximum workload the team management had targeted for the bowler after he spent three months on the sidelines with a back injury before returning to action in April.
England line-up for fifth Test vs India: 1. Zak Crawley, 2. Ben Duckett, 3. Ollie Pope (c), 4. Joe Root, 5. Harry Brook, 6. Jacob Bethell, 7. Jamie Smith (wk), 8. Chris Woakes, 9. Gus Atkinson, 10. Jamie Overton, 11. Josh Tongue
Watch the fifth Test between England and India, at The Kia Oval, live on Sky Sports Cricket from Thursday or stream without a contract. Build-up begins at 10am ahead of the first ball at 11am.
England vs India - results and schedule
All games at 11am UK and Ireland; all on Sky Sports
- First Test (Headingley) - England won by five wickets
- Second Test (Edgbaston) - India won by 336 runs
- Third Test (Lord's) - England won by 22 runs
- Fourth Test (Emirates Old Trafford) - Match drawn
- Fifth Test (The Kia Oval): July 31 - August 4